Lossofheterozygositysomaticmutation

由 H Khiabanian 著作 · 2018 · 被引用 19 次 — In this study, we address this problem and introduce LOHGIC (LOH-germline inference calculator) to assess germline versus somatic status of ...

由 GL Ryland 著作 · 2015 · 被引用 158 次 — Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type ...

Loss of heterozygosity (LOH) is a type of genetic abnormality in diploid organisms in which one copy of an entire gene and its surrounding chromosomal ...

由 KK Takahashi 著作 · 2022 · 被引用 3 次 — Deletion and uniparental disomy (UPD) have been well documented as the mechanisms of LOH, but the role of gene conversion is poorly understood.

3 天前 — It is a common form of allelic imbalance by which heterozygous somatic cells become homozygous because one of the two alleles gets lost. This ...

由 CA Nichols 著作 · 2020 · 被引用 70 次 — LOH occurs when a cancer cell that is originally heterozygous at a locus loses one of its two alleles at that locus, either by simple deletion ...

由 GL Ryland 著作 · 2015 · 被引用 158 次 — Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type ...

由 X Zhang 著作 · 2021 · 被引用 31 次 — Loss of heterozygosity (LOH) is a common genetic event in the development of cancer and is known to play an essential role in the somatic loss ...

2023年11月15日 — Loss of heterozygosity (LOH) refers to a specific type of genetic mutation during which there is a loss of one normal copy of a gene or a ...